5[prime] to 3[prime] nucleic acid synthesis using 3[prime]-photoremovable protecting group
Patent
·
OSTI ID:6478659
The present invention relates, in general, to a method of synthesizing a nucleic acid, and, in particular, to a method of effecting 5[prime] to 3[prime] nucleic acid synthesis. The method can be used to prepare arrays of oligomers bound to a support via their 5[prime] end. The invention also relates to a method of effecting mutation analysis using such arrays. The invention further relates to compounds and compositions suitable for use in such methods.
- Sponsoring Organization:
- DOE; USDOE, Washington, DC (United States)
- DOE Contract Number:
- FG05-92ER61388
- Assignee:
- Duke Univ., Durham, NC (United States)
- Patent Number(s):
- A; US 5908926
- Application Number:
- PPN: US 8-406327
- OSTI ID:
- 6478659
- Country of Publication:
- United States
- Language:
- English
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