Clearance and localization of intravitreal liposomes in the aphakic vitrectomized eye

Journal Article · Fri May 01 04:00:00 EDT 1987 · Invest. Ophthalmol. Visual Sci.; (United States)

OSTI ID:6477111

Stern, W H; Heath, T D; Lewis, G P; Guerin, C J; Erickson, P A; Lopez, N G; Hong, K L

The authors have examined the fate of intravitreally injected liposomes in the aphakic, vitrectomized eye of the rabbit. Liposomes labelled with /sup 125/(I)-p-hydroxybenzimidylphosphatidylethanolamine were eliminated rapidly from the intraocular fluid. Nonetheless, a significant fraction of these liposomes were found to bind to various ocular tissues including the retina, iris, sclera, and cornea. Ultrastructural studies with gold colloid-loaded liposomes revealed that retinal bound liposomes were attached to the inner limiting lamina but did not penetrate to the internal cells of the retina. Epiretinal cells bound and internalized gold colloid-loaded liposomes suggesting that these cells may be very sensitive to liposome mediated drug delivery.

• Research Organization: Univ. of California, San Francisco
• OSTI ID: 6477111
• Journal Information: Invest. Ophthalmol. Visual Sci.; (United States), Journal Name: Invest. Ophthalmol. Visual Sci.; (United States) Vol. 5; ISSN IOVSD
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BIOLOGICAL LOCALIZATION
BODY
BODY AREAS
CELL CONSTITUENTS
CLEARANCE
COLLOIDS
DISEASES
DISPERSIONS
DISTRIBUTION
DRUGS
EYES
FACE
HALOGEN COMPOUNDS
HEAD
IODINE COMPOUNDS
LABELLED COMPOUNDS
LIPOSOMES
MAMMALS
ORGANOIDS
ORGANS
RABBITS
RADIOCOLLOIDS
RADIOPHARMACEUTICALS
RETINA
SENSE ORGANS
SENSE ORGANS DISEASES
TISSUE DISTRIBUTION
VERTEBRATES