Morphology and metastatic nature of induced hepatic nodular lesions in C57BL x C3H F/sub 1/ mice

Journal Article · Sat Jul 01 04:00:00 EDT 1978 · Cancer Res.; (United States)

OSTI ID:6475949

Vesselinovitch, S D; Mihailovich, N; Rao, K V.N.

The metastatic capabilities of well-defined nodular hepatic lesions induced by benzo(a)pyrene, ethylnitrosourea, benzidine 2HCl, and diethylnitrosamine were evaluated. Coded liver and lung tissues from 1264 treated C57BL/6J x C3HeB/FeJ F/sub 1/ mice were assessed independently for the presence of primary nodular lesions and metastases, respectively. Primary lesions were classified according to their size, cell morphology, and growth patterns into hyperplastic, adenomatous, and trabecular nodules. None of the 126 mice bearing hyperplastic nodules had pulmonary metastases. Four of 291 (1.4%) mice with adenomatous nodular lesions showed metastases. In contrast, of the 733 mice bearing the trabecular type of nodular lesions alone or in combination with other lesions, 266 (36%) showed pulmonary metastases. The pulmonary metastases were first detected in mice dying between 51 and 60 weeks of age (5%). This rate increased as a function of age at death, reaching an incidence of 51% in mice surviving more than 81 weeks. It was concluded that nodules showing trabecular and the more anaplastic solid sheet type of growths represented bona fide hepatocellular carcinomas in the mouse.

• Research Organization: Univ. of Chicago, IL
• OSTI ID: 6475949
• Journal Information: Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 38; ISSN CNREA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADENOMAS
AMINES
ANIMALS
AROMATICS
BENZIDINE
BENZOPYRENE
BIOASSAY
BIOLOGICAL EFFECTS
BODY
CARCINOGENS
CARCINOMAS
CONDENSED AROMATICS
DIGESTIVE SYSTEM
DISEASES
GLANDS
GROWTH
HISTOLOGY
HYDROCARBONS
LIVER
LUNGS
MAMMALS
METASTASES
MICE
MORPHOLOGY
NEOPLASMS
ORGANIC COMPOUNDS
ORGANS
RESPIRATORY SYSTEM
RODENTS
SURVIVAL CURVES
VERTEBRATES