Prenatal multicarcinogenesis by ethylnitrosourea in mice

Journal Article · Wed Jun 01 04:00:00 EDT 1977 · Cancer Res.; (United States)

OSTI ID:7026827

Vesselinovitch, S D; Koka, M; Rao, K V.N.; Mihailovich, N; Rice, J M

The role of prenatal age, sex, and the maternal background upon the incidence, multiplicity, and spectrum of tumors induced by ethylnitrosourea has been studied in the offspring of reciprocal hybrids of the same genotype. The first generation (F/sub 1/) offspring of C57BL/6J x C3HeB/FeJ and the reciprocal hybrids were observed throughout their life-span for tumor development following single i.p. injections of ethylnitrosourea (60 ..mu..g/g) given to pregnant mothers at 12, 14, 16, or 18 days of gestation. Animals exposed to ethylnitrosourea survived on the average for only 90 weeks. They developed by that age tumors in lungs, livers, ovaries, nervous system, and forestomach. Control mice killed at 90 weeks were essentially free of tumors. The fetal age at the time of adminstration of the carcinogen was one of the most significant modulators of tumor development in lung, liver, ovaries, and nervous system. The sex of the animals influenced the rate of development of liver tumors, whereas material background affected the multiplicity of lung tumors.

• Research Organization: Univ. of Chicago
• OSTI ID: 7026827
• Journal Information: Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 37; ISSN CNREA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AGE GROUPS
ANIMALS
BIOLOGICAL EFFECTS
BODY
CARCINOGENESIS
CARCINOGENS
DIGESTIVE SYSTEM
DISEASES
FEMALE GENITALS
GENOTYPE
GLANDS
GONADS
HYBRIDIZATION
LIFE SPAN
LIVER
LUNGS
MAMMALS
MICE
NEOPLASMS
NERVOUS SYSTEM
ORGANS
OVARIES
PATHOGENESIS
PREGNANCY
PROGENY
RESPIRATORY SYSTEM
RODENTS
SEX
VERTEBRATES