Metastatic rate of liver tumors induced by diethylnitrosamine in mice

Journal Article · Fri Nov 01 04:00:00 EST 1974 · Cancer Res.; (United States)

OSTI ID:5340440

Kyriazis, A P; Koka, M; Vesselinovitch, S D

The metastatic capability of liver tumors induced in 220 C57BL/6J x C3HeB/FeJ F/sub 1/ mice by diethylnitrosamine was studied. Microscopically primary liver tumors showed a predominantly trabecular pattern with varying degrees of cellular atypia. The invasion of the portal vessels by tumor cells was seen occasionally. Detailed histological examination of the lung tissue revealed metastatic foci in 22% of animals bearing primary liver tumors. Tumors metastasized mainly by the hematogenous route; the metastases were multifocal, often of microscopic size, with isolated foci showing a tendency to coalesce and form larger tumor masses. Areas of diffuse infiltration of the lung parenchyma were also seen. The metastatic capability of diethylnitrosamine-induced liver tumors further substantiated their frank neoplastic nature. Detection of high rate of lung metastases was made possible only through the detailed examination of the whole lungs, regardless of whether or not macroscopic changes were present at autopsy.

• Research Organization: Univ. of Chicago
• OSTI ID: 5340440
• Journal Information: Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 34; ISSN CNREA
• Country of Publication: United States
• Language: English

Related Subjects

550900* -- Pathology
560306 -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMAL CELLS
ANIMALS
BODY
CARCINOGENS
DIGESTIVE SYSTEM
DISEASES
GLANDS
LIVER
LUNGS
MAMMALS
METABOLISM
METASTASES
MICE
NEOPLASMS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
RESPIRATORY SYSTEM
RODENTS
TUMOR CELLS
VERTEBRATES