Changes in delayed hypersensitivity reaction in mice exposed to O/sub 3/
BALB/c mice were continuously exposed to 0.8 ppm O/sub 3/ for 1, 3, 7, and 14 days. Ozone exposure suppressed the delayed hypersensitivity (DH) reaction to sheep red blood cells (SRBC). The maximum effect was seen after 7 days of exposure. To estimate the suppression of the DH reaction by O/sub 3/ exposure, the numbers of lymphocytes in thymus and blood of exposed mice were compared with those of control mice. A decrease in the numbers of lymphocytes in both thymus and blood was observed in O/sub 3/-exposed mice. The percentage of T and B lymphocytes in blood of exposed mice was the same as that in blood of control mice. These results suggest that 0.8 ppm O/sub 3/ exposure affects the T lymphocytes required for DH reactions.
- Research Organization:
- National Institute for Environmental Studies, Ibaraki, Japan
- OSTI ID:
- 6465355
- Journal Information:
- Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 1; ISSN ENVRA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Effect of subacute exposure to NO/sub 2/ on lymphocytes required for antibody responses
Suppression of antibody response in mice by acute exposure to nitrogen dioxide: in vitro study
Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CELL PROLIFERATION
CONNECTIVE TISSUE CELLS
DOMESTIC ANIMALS
ERYTHROCYTES
IMMUNE REACTIONS
LEUKOCYTES
LYMPHATIC SYSTEM
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
ORGANS
OZONE
RODENTS
RUMINANTS
SENSITIVITY
SHEEP
SOMATIC CELLS
THYMUS
VERTEBRATES