Effect of subacute exposure to NO/sub 2/ on lymphocytes required for antibody responses

Journal Article · Tue Nov 30 23:00:00 EST 1982 · Environ. Res.; (United States)

OSTI ID:5144608

Fujimaki, H; Shimizu, F; Kubota, K

BALB/c mice were continuously exposed to 0.4 and 1.6 ppm NO/sub 2/ for 4 weeks and the effects on lymphocytes which are required for primary and secondary antibody responses to sheep red blood cells were examined in vitro. The primary antibody response was significantly suppressed by both concentrations of NO/sub 2/, whereas the secondary antibody response was slightly stimulated by 1.6 ppm NO/sub 2/ exposure. In reconstitution experiments no significant differences were observed in the activities of T and B lymphocytes from mice exposed to 1.6 ppm NO/sub 2/.

• Research Organization: National Inst. for Environmental Studies, Yatabe-machi Tsukuba Ibaraki, Japan
• OSTI ID: 5144608
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 29:2; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIBODY FORMATION
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHALCOGENIDES
CHRONIC EXPOSURE
CONNECTIVE TISSUE CELLS
IN VITRO
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
OXIDES
OXYGEN COMPOUNDS
RODENTS
SOMATIC CELLS
VERTEBRATES