Suppression of antibody response in mice by acute exposure to nitrogen dioxide: in vitro study

Journal Article · Tue Dec 01 04:00:00 EST 1981 · Environ. Res.; (United States)

OSTI ID:5627694

Hidekazu, F; Shimizu, F; Kubota, K

The effect of acute exposure to nitrogen dioxide (NO/sub 2/) on in vitro primary and secondary antibody responses to sheep red blood cells (SRBC) was studied in BALB/c mice. After the in vivo exposure to 20 ppm NO/sub 2/ for 12 hr, spleen cells were separated and then cultured with SRBC. Cell reconstitution experiments indicated that in the primary antibody response B cells were more strongly suppressed than T cells, while in the secondary response suppression of primed T cells was greater than that of prime B cells.

• Research Organization: National Inst. For Environmental Studies, Chiba, Japan
• OSTI ID: 5627694
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 26:2; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIBODIES
ANTIGEN-ANTIBODY REACTIONS
BIOLOGICAL EFFECTS
BODY
CHALCOGENIDES
IN VITRO
IN VIVO
MAMMALS
MICE
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
ORGANS
OXIDES
OXYGEN COMPOUNDS
RESPONSE MODIFYING FACTORS
RODENTS
SPLEEN
VERTEBRATES