Effects of acute exposure to nitrogen dioxide on primary antibody response

Journal Article · Fri May 01 04:00:00 EDT 1981 · Arch. Environ. Health; (United States)

DOI:https://doi.org/10.1080/00039896.1981.10667614· OSTI ID:6317573

Hidekazu, F; Fujio, S

The effects of acute exposure to nitrogen dioxide on primary humoral antibody response to sheep red blood cells in mice were studied. Mice were exposed to 5 ppM, 20 ppM, and 40 ppM nitrogen dioxide for 12 h. An exposure of 20 ppM or 40 ppM resulted in a significant suppression of antibody responses, but 5 ppM did not affect antibody response. This immunosuppression resulting from nitrogen dioxide exposure was more apparent in males than females. Exposures to 20 ppM nitrogen dioxide for various time intervals revealed that the strongest suppression effect was observed in the group exposed 2 days after antigen injection. A decreased total cell number in the spleen, and more strikingly, in the thymus, was also caused by acute exposure to nitrogen dioxide.

• Research Organization: National Inst. for Environmental Studies, Ibaraki, Japan
• OSTI ID: 6317573
• Journal Information: Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 36:3; ISSN AEHLA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIBODIES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CHALCOGENIDES
COMPARATIVE EVALUATIONS
DATA
DOMESTIC ANIMALS
ERYTHROCYTES
EXPERIMENTAL DATA
FEMALES
IMMUNOSUPPRESSION
INFORMATION
MALES
MAMMALS
MATERIALS
MICE
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
NUMERICAL DATA
ORGANS
OXIDES
OXYGEN COMPOUNDS
RODENTS
RUMINANTS
SHEEP
SPLEEN
TRACE AMOUNTS
VERTEBRATES