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Biological effects of accelerated heavy ions. II. Fractionated irradiation of intestinal crypt cells

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3575469· OSTI ID:6460406
; ;
The survival of jejunal crypt cells was measured following irradiation in 1, 2, 5, or 10 fractions in beams of accelerated helium, carbon, neon, or argon ions. The beams were modulated to spread the Bragg peak in order to approximate the geometry anticipated in clinical applications. There was less recovery in cells irradiated in the peak regions than in the plateau regions for all the beams. For neon with a 4-cm spread out Bragg peak (SOBP) and for argon with a 10-cm SOBP, fractionated irradiation was more effective than single-dose irradiation. Multifraction irradiation in high-LET beams enhanced the peak-to-plateau relative biological effectiveness ratio compared to single-fraction irradiation, and therefore fractionation inproved the biological depth-dose distribution of charged-particle beams.
Research Organization:
Univ. of California, San Francisco
OSTI ID:
6460406
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 86:3; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ARGON IONS
BEAMS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
CARBON IONS
CHARGED PARTICLES
CRYPT CELLS
DEPTH DOSE DISTRIBUTIONS
ENERGY TRANSFER
FRACTIONATED IRRADIATION
HELIUM IONS
ION BEAMS
IONS
IRRADIATION
LET
NEON IONS
RADIATION DOSE DISTRIBUTIONS
RADIATION EFFECTS
RBE
RECOVERY
SOMATIC CELLS
SPATIAL DOSE DISTRIBUTIONS
SURVIVAL CURVES