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Biological effects of accelerated heavy ions. I. Single dose in normal tissue, tumors, and cells in vitro

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3575468· OSTI ID:6195909
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To characterize beams of possible use in radiotherapy, the survival of jejunal crypt cells, EMT 6 tumor cells in flank tumors, and hypoxic and euoxic EMT 6 tumor cells in vitro was studied following irradiation in beams of accelerated helium, carbon, neon, or argon ions. The beams were modified with a varable-thickness absorber to give a 4-cm spread out Bragg peak (SOBP) and therefore approximated the kind of beam geometry anticipated for the clinical application of high-LET beams. The RBE was higher in cells in the EMT 6 tumor than in the gut, and higher for hypoxic cells than for euoxic cells. The RBE increased with increasing LET up to aproximately 100 keV/..mu..m. The RBE was higher for the peak region than for the plateau region of the helium, carbon, and neon beams leading to a favorable biological depth-dose distribution measured as the peak-to-plateau RBE ratio. The argon beam had an unfavorable peak-to-plateau RBE ratio.
Research Organization:
Univ. of California, San Francisco
OSTI ID:
6195909
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 86:3; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ANIMAL CELLS
ANOXIA
ARGON IONS
BEAMS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BRAGG CURVE
CARBON IONS
CESIUM 137
CESIUM ISOTOPES
CHARGED PARTICLES
CRYPT CELLS
DIAGRAMS
ENERGY TRANSFER
HELIUM IONS
IN VITRO
ION BEAMS
IONS
ISOTOPES
LET
NEON IONS
NUCLEI
ODD-EVEN NUCLEI
RADIATION EFFECTS
RADIOISOTOPES
RBE
SOMATIC CELLS
SURVIVAL CURVES
TUMOR CELLS
YEARS LIVING RADIOISOTOPES