(/sup 18/F)-labeled 3-deoxy-3-fluoro-D-glucose: synthesis and preliminary biodistribution data

Journal Article · Thu Nov 30 23:00:00 EST 1978 · J. Nucl. Med.; (United States)

OSTI ID:6459504

Tewson, T J; Welch, M J; Raichle, M E

A cyclotron target system for the production of anhydrous (/sup 18/F) fluoride ion was developed and used for the synthesis of carrier-free (/sup 18/F)-3-deoxy-3-fluoro-D-glucose (3-FDG). The synthesis is sufficiently rapid and efficient to allow production of usable amounts of 3-FDG with a 6-MeV cyclotron. Preliminary animal studies show that 3-FDG is in fact a glucose analog.

• Research Organization: Mallinckrodt Inst. of Radiology, St. Louis, MO
• OSTI ID: 6459504
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 19:12; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702* -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550501 -- Metabolism-- Tracer Techniques
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
551001 -- Physiological Systems-- Tracer Techniques
560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACCELERATORS
ALDEHYDES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLADDER
BODY
BRAIN
CARBOHYDRATES
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
CHEMICAL PREPARATION
CHEMISTRY
COUNTING TECHNIQUES
CYCLIC ACCELERATORS
CYCLOTRONS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
FLUORINE 18
FLUORINE ISOTOPES
GLANDS
GLUCOSE
HEART
HEXOSES
HOURS LIVING RADIOISOTOPES
INJECTION
INTAKE
ISOTOPE PRODUCTION
ISOTOPES
LABELLED COMPOUNDS
LABELLING
LIGHT NUCLEI
LIVER
METABOLISM
MONOSACCHARIDES
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC FLUORINE COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
RADIOACTIVE MATERIALS
RADIOCHEMISTRY
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
SACCHARIDES
SCINTISCANNING
SYNTHESIS
TISSUE DISTRIBUTION
URINARY TRACT