New method using anhydrous (/sup 18/F)fluoride to radiolabel 2-(/sup 18/F)fluoro-2-deoxy-D-glucose
Journal Article
·
· J. Nucl. Med.; (United States)
OSTI ID:6862362
A new chemical route for the preparation of 2-(/sup 18/F)fluoro-2-deoxy-D-glucose (2-/sup 18/FDG) is discussed using anhydrous (/sup 18/F)fluoride produced by the /sup 20/Ne(d,..cap alpha..)/sup 18/F reaction. The anhydous /sup 18/F/sup -/ is reacted with a previously prepared precursor, methyl 4,6-o-benzylidene-3-o-methyl-2-O-trifluoromethanesulfonyl-..beta..-D-mannopyranoside, in dimethyl formamide or hexamethylophosphoric triamide. The corresponding fluoro-deoxy-glucose derivative, upon treatment with borontribromide or concentrated hydrochloric acid, yields 2-/sup 18/FDG in 10% (overall) yield. The substrate was characterized by thin-layer chromatography (TLC), and high-performance liquid chromatography (HPLC). Biodistribution studies were performed in mice, and imaging studies in dogs.
- Research Organization:
- Massachusetts General Hospital, Boston
- OSTI ID:
- 6862362
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 23:10; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
Similar Records
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Process for the production of .sup.18 F-2-deoxy-2-fluoro-D-glucose
New improved synthesis of 2-deoxy-2-(/sup 18/F)fluoro-d-glucose from /sup 18/F-labeled acetyl hypofluorite
Conference
·
Wed May 01 00:00:00 EDT 1985
· J. Nucl. Med.; (United States)
·
OSTI ID:6759345
Process for the production of .sup.18 F-2-deoxy-2-fluoro-D-glucose
Patent
·
Tue Dec 31 23:00:00 EST 1985
·
OSTI ID:866024
New improved synthesis of 2-deoxy-2-(/sup 18/F)fluoro-d-glucose from /sup 18/F-labeled acetyl hypofluorite
Journal Article
·
Fri Oct 01 00:00:00 EDT 1982
· J. Nucl. Med.; (United States)
·
OSTI ID:6592002
Related Subjects
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702* -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CARBOHYDRATES
CHEMICAL PREPARATION
CHROMATOGRAPHY
DISTRIBUTION
DOGS
FLUORINE 18
FLUORINE ISOTOPES
HEXOSES
HOURS LIVING RADIOISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
LIQUID COLUMN CHROMATOGRAPHY
MAMMALS
MICE
MONOSACCHARIDES
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC FLUORINE COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
RADIOISOTOPES
RODENTS
SACCHARIDES
SEPARATION PROCESSES
SYNTHESIS
THIN-LAYER CHROMATOGRAPHY
TISSUE DISTRIBUTION
VERTEBRATES
400702* -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CARBOHYDRATES
CHEMICAL PREPARATION
CHROMATOGRAPHY
DISTRIBUTION
DOGS
FLUORINE 18
FLUORINE ISOTOPES
HEXOSES
HOURS LIVING RADIOISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
LIQUID COLUMN CHROMATOGRAPHY
MAMMALS
MICE
MONOSACCHARIDES
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC FLUORINE COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
RADIOISOTOPES
RODENTS
SACCHARIDES
SEPARATION PROCESSES
SYNTHESIS
THIN-LAYER CHROMATOGRAPHY
TISSUE DISTRIBUTION
VERTEBRATES