New method using anhydrous (/sup 18/F)fluoride to radiolabel 2-(/sup 18/F)fluoro-2-deoxy-D-glucose

Journal Article · Fri Oct 01 00:00:00 EDT 1982 · J. Nucl. Med.; (United States)

OSTI ID:6862362

Levy, S; Elmaleh, D R; Livni, E

A new chemical route for the preparation of 2-(/sup 18/F)fluoro-2-deoxy-D-glucose (2-/sup 18/FDG) is discussed using anhydrous (/sup 18/F)fluoride produced by the /sup 20/Ne(d,..cap alpha..)/sup 18/F reaction. The anhydous /sup 18/F/sup -/ is reacted with a previously prepared precursor, methyl 4,6-o-benzylidene-3-o-methyl-2-O-trifluoromethanesulfonyl-..beta..-D-mannopyranoside, in dimethyl formamide or hexamethylophosphoric triamide. The corresponding fluoro-deoxy-glucose derivative, upon treatment with borontribromide or concentrated hydrochloric acid, yields 2-/sup 18/FDG in 10% (overall) yield. The substrate was characterized by thin-layer chromatography (TLC), and high-performance liquid chromatography (HPLC). Biodistribution studies were performed in mice, and imaging studies in dogs.

• Research Organization: Massachusetts General Hospital, Boston
• OSTI ID: 6862362
• Journal Information: J. Nucl. Med.; (United States), Vol. 23:10
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
FLUORINE 18
TISSUE DISTRIBUTION
LABELLED COMPOUNDS
CHEMICAL PREPARATION
ORGANIC FLUORINE COMPOUNDS
ALDEHYDES
DOGS
HEXOSES
LIQUID COLUMN CHROMATOGRAPHY
MICE
THIN-LAYER CHROMATOGRAPHY
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CARBOHYDRATES
CHROMATOGRAPHY
DISTRIBUTION
FLUORINE ISOTOPES
HOURS LIVING RADIOISOTOPES
ISOTOPES
LIGHT NUCLEI
MAMMALS
MONOSACCHARIDES
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
RADIOISOTOPES
RODENTS
SACCHARIDES
SEPARATION PROCESSES
SYNTHESIS
VERTEBRATES
400702* - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials
560172 - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)