Technique for determination of human zinc absorption from measurement of radioactivity in a fecal sample or the body

Journal Article · Wed Dec 01 04:00:00 EST 1982 · Gastroenterology; (United States)

OSTI ID:6456337

Payton, K B; Flanagan, P R; Stinson, E A; Chodirker, D P; Chamberlain, M J; Valberg, L S

The intestinal absorption of an oral dose of zinc chloride was determined from the ratio of /sup 65/Zn and a nonabsorbed radioactive marker, /sup 51/Cr, present in a single stool specimen or the body 24-72 h later. Chromic chloride had no effect on (/sup 65/Zn)zinc chloride absorption and /sup 51/Cr and /sup 65/Zn had similar intestinal transit times. In 17 healthy control subtects given 92 mumol ZnCl/sub 2/ labeled with 0.5 microCi /sup 65/Zn, 52 +/- 14% (SD) of the dose was taken up from the lumen. Intestinal absorption of /sup 65/Zn at 24 h correlated closely with /sup 65/Zn body retention of zinc measured by whole-body counting 7 days later, r . 0.995. Neither zinc absorption nor zinc retention correlated with blood leukocyte zinc levels. An average of 55% of /sup 65/Zn was retained in the body from doses of 18-90 mumol ZnCl/sub 2/ but a progressively smaller proportion of zinc was absorbed from doses of 180-900 mumol. The average absorption and body retention of /sup 65/Zn were significantly reduced in 7 patients with mucosal disease of the proximal intestine but they were not affected by resection of the lower jejunum, ileum, and colon. Thus the absorption of ZnCl/sub 2/ from a 92-mumol dose predominantly takes place by a rate-limited mechanism in the duodenum and upper jejunum.

• Research Organization: Departments of Medicine and Nuclear Medicine, University Hospital, London, Ontario, Canada
• OSTI ID: 6456337
• Journal Information: Gastroenterology; (United States), Journal Name: Gastroenterology; (United States) Vol. 83:6; ISSN GASTA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
ABSORPTION
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BLOOD CELLS
BODY FLUIDS
CHLORIDES
CHLORINE COMPOUNDS
CHROMIUM 51
CHROMIUM ISOTOPES
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM DISEASES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
FECES
HALIDES
HALOGEN COMPOUNDS
INTERMEDIATE MASS NUCLEI
INTESTINAL ABSORPTION
ISOTOPE APPLICATIONS
ISOTOPES
LEUKOCYTES
MATERIALS
MEMBRANES
METALS
MUCOUS MEMBRANES
NUCLEI
PATHOLOGY
PATIENTS
RADIOISOTOPES
RETENTION
UPTAKE
WASTES
ZINC
ZINC 65
ZINC CHLORIDES
ZINC COMPOUNDS
ZINC HALIDES
ZINC ISOTOPES