Effects of iron, tin, and copper on zinc absorption in humans

Journal Article · Sat Sep 01 04:00:00 EDT 1984 · Am. J. Clin. Nutr.; (United States)

OSTI ID:6237897

Valberg, L S; Flanagan, P R; Chamberlain, M J

Zinc absorption as measured by body retention of (65Zn)zinc chloride or a turkey test meal extrinsically labeled with 65Zn was determined in human subjects by whole body counting after 7 days. Average 65Zn absorption from zinc chloride in persons with a high iron-absorbing capacity was similar to persons with a low capacity to absorb iron. Inorganic iron, 920 mumol (51 mg), or HB iron, 480 mumol (26 mg), inhibited 65Zn absorption from 92 mumol (6 mg) of zinc chloride. When 610 mumol of iron (34 mg) was added to a turkey test meal containing 61 mumol of zinc (4 mg), 65Zn absorption was not inhibited. Tin, 306 mumol (36 mg), given with zinc chloride or turkey test meals (61 mumol, 4 mg, of Zn) significantly reduced 65Zn absorption. Copper, 79 mumol (5 mg), had no significant effect on the 65Zn absorption from 7.9 mumol (0.5 mg) of zinc chloride. In summary, the capacity to absorb iron did not influence 65Zn absorption, but both inorganic iron and heme-iron inhibited 65Zn absorption from zinc chloride. Inorganic iron had no effect, however, on 65Zn absorption from the turkey test meal. Tin in a large dose also inhibited 65Zn absorption from both zinc chloride and the turkey test meal.

• Research Organization: Univ. Hospital, London, Ontario, Canada
• OSTI ID: 6237897
• Journal Information: Am. J. Clin. Nutr.; (United States), Journal Name: Am. J. Clin. Nutr.; (United States) Vol. 40:3; ISSN AJCNA
• Country of Publication: United States
• Language: English

Related Subjects

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560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
COPPER
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
INTESTINAL ABSORPTION
IRON
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MAN
METALS
NUCLEI
PRIMATES
RADIOISOTOPES
TIN
TRACER TECHNIQUES
TRANSITION ELEMENTS
UPTAKE
VERTEBRATES
WHOLE-BODY COUNTING
ZINC
ZINC 65
ZINC ISOTOPES