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Effect of aging and radiation in mice of different genotypes

Journal Article · · Birth Defects, Orig. Artic. Ser.; (United States)
OSTI ID:6451766
This report deals with the effects of genotype and of radiation exposure on the life table of mice. Life table data are provided for 9 inbred strains and 5 hybrids. Effects of radiation on the life table are reported for 4 inbred strains and 4 hybrid populations. There were no particular surprises in the data or remarkable new insights resulting from them. Many of the same general conclusions have been reached previously by other investigators. This data has the advantage of reasonably large sample sizes with a consequent statistical reliability. Further, the data were collected concurrently in the same laboratory within a common environment and animal husbandry procedures. The conclusions, while in some cases not new, are often lost sight of and therefore deserve reemphasis. Any modeling of or hypotheses concerning aging should be in concordance with these observations.
OSTI ID:
6451766
Journal Information:
Birth Defects, Orig. Artic. Ser.; (United States), Journal Name: Birth Defects, Orig. Artic. Ser.; (United States) Vol. 14:1; ISSN BTHDA
Country of Publication:
United States
Language:
English