Types and rate of cataract development in mice irradiated at different ages. [X Radiation]

Journal Article · Mon Aug 01 04:00:00 EDT 1977 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3574688· OSTI ID:7083106

Gajewski, A K ^[1]; Majewska, K; Slowikowska, M G; Chomiczewski, K; Kulig, A

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1. National Inst. of Hygiene, Warsaw

The effect of age on the development of radiation cataract has been investigated in an inbred A strain of mice and, as a result, the patterns of age dependence and senile mice cataract development were obtained. In general, the lenses of mice 1 to 3 days old were the most sensitive to radiation; the maximum resistance was noted in 5-day-old mice, and from this age up to 3 to 7 weeks of life there was a period of increasing sensitivity. In older animals the lens sensitivity tends to level off. The early stages of cataract occurred in all irradiated groups at a younger age than in the control group, but the late stages occurred in irradiated groups at the same age as the senile cataract occurred in the control group. Two types of cataract were observed. One was typical for young irradiated mice 1 to 5 days of age and the other was typical for all remaining irradiated groups and for a control group. Also, an attempt was made to correlate the obtained results with the cell kinetics in normal lens epithelium.

• OSTI ID: 7083106
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 71:2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CATARACTS
CRYSTALLINE LENS
DISEASES
ELECTROMAGNETIC RADIATION
EYES
IONIZING RADIATIONS
MAMMALS
MICE
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RODENTS
SENSE ORGANS
SENSE ORGANS DISEASES
VERTEBRATES
X RADIATION