Armitage-Doll two-stage model: Implications and extension

Journal Article · Tue Jun 01 00:00:00 EDT 1993 · Risk Analysis; (United States)

DOI:https://doi.org/10.1111/j.1539-6924.1993.tb01079.x· OSTI ID:6444705

Chen, C W ^[1]

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1. Environmental Protection Agency, Washington, DC (United States)

The objective of this paper is twofold: (1) to provide insight on the simplified MVK model of carcinogenesis (a model proposed by Moolgavkar and colleagues) by revealing the relationship between the Armitage-Doll two-stage model and the simplified MVK model; and (2) to extend the Armitage-Doll two-stage model to one with time-varying (piece-wise constant) parameters. It is shown that the simplified MVK model is a special case of the Armitage-Doll two-stage model, and many applications of the simplified MVK model involving intermittent exposures or exposures to different compounds in different time periods can be derived easily from the Armitage-Doll two-stage model with piece-wise constant parameters. The limitations of the Armitage-Doll two-stage model are discussed. 24 refs., 3 figs.

• OSTI ID: 6444705
• Journal Information: Risk Analysis; (United States), Journal Name: Risk Analysis; (United States) Vol. 13:3; ISSN 0272-4332; ISSN RIANDF
• Country of Publication: United States
• Language: English

Related Subjects

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COMPARATIVE EVALUATIONS
DOSE-RESPONSE RELATIONSHIPS
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MATHEMATICAL MODELS
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RADIATION DOSE DISTRIBUTIONS
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