Carcinogenic risk assessment with time-dependent exposure patterns

Journal Article · Wed Nov 30 23:00:00 EST 1988 · Risk Anal.; (United States)

DOI:https://doi.org/10.1111/j.1539-6924.1988.tb01192.x· OSTI ID:6288877

Murdoch, D J; Krewski, D

Previous applications of carcinogenic risk assessment using mathematical models of carcinogenesis have focused largely on the case where the level of exposure remains constant over time. In many situations, however, the dose of the carcinogen varies with time. In this paper, the authors discuss both the classical Armitage-Doll multistage model and the Moolgavkar-Venzon-Knudson two-stage birth-death-mutation model with time-dependent dosing regimens. Bounds on the degree of underestimation of risk that can occur through the use of a simple time-weighted average dose are derived by means of comparison with an equivalent constant dose corresponding to the actual risk under the time-dependent dosing regimen.

• Research Organization: Health Protection Branch, Health and Welfare Canada, Ottawa, Ontario
• OSTI ID: 6288877
• Journal Information: Risk Anal.; (United States), Journal Name: Risk Anal.; (United States) Vol. 8:4; ISSN RIAND
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BODY
CARCINOGENESIS
CARCINOGENS
DEATH
DISEASES
DOSE LIMITS
DOSE RATES
DOSE-RESPONSE RELATIONSHIPS
HAZARDS
HEALTH HAZARDS
HUMAN POPULATIONS
MATHEMATICAL MODELS
MUTATIONS
NEOPLASMS
ORGANS
PATHOGENESIS
POPULATIONS
PROMOTERS
RISK ASSESSMENT
SAFETY STANDARDS
STANDARDS
STATISTICAL MODELS
TIME DEPENDENCE
TISSUES
TUMOR PROMOTERS