Carcinogenesis models: An overview
- Fred Hutchinson Cancer Research Center, Seattle, WA (United States)
Biologically based mathematical models of carcinogenesis are not only an essential part of a rational approach to quantitative cancer risk assessment but also raise fundamental questions about the nature of the events leading to malignancy. In this paper two such models are reviewed. The first is the multistage model proposed by Armitage and Doll in the 1950s; most of the paper is devoted to a discussion of the two-mutation model proposed by the author and his colleagues. This model is a generalization of the idea of recessive oncogenesis proposed by Knudson and has been shown to be consistent with a large body of epidemiologic and experimental data. The usefulness of the model is illustrated by analyzing a large experimental data set in which rats exposed to radon developed malignant lung tumors.
- OSTI ID:
- 44909
- Report Number(s):
- CONF-901010--Pt.2
- Country of Publication:
- United States
- Language:
- English
Similar Records
Initiation, promotion, initiation experiments with radon and cigarette smoke: Lung tumors in rats
Armitage-Doll two-stage model: Implications and extension