How tautological are interspecies correlations of carcinogenic potencies

Journal Article · Tue Jun 01 00:00:00 EDT 1993 · Risk Analysis; (United States)

DOI:https://doi.org/10.1111/j.1539-6924.1993.tb01078.x· OSTI ID:6438467

Freedman, D A ^[1]; Gold, L S; Slone, T H ^[2]

---

1. Univ. of California, Berkeley (United States)
2. Lawrence Berkeley Lab., CA (United States)

Crouch and Wilson demonstrated a strong correlation between carcinogenic potencies in rats and mice, supporting the extrapolation from mouse to man. Bernstein et al., however, show that the observed correlation is mainly a statistical artifact of bioassay design. Crouch et al. responded to the conclusions of Bernstein et al. with further arguments in support of their (Crouch et al.) initial correlations. This paper reviews the arguments of both groups and presents some new data. The correlation is largely (but not totally) tautological, confirming results in Bernstein et al. 29 refs., 1 fig., 4 tabs.

• OSTI ID: 6438467
• Journal Information: Risk Analysis; (United States), Journal Name: Risk Analysis; (United States) Vol. 13:3; ISSN 0272-4332; ISSN RIANDF
• Country of Publication: United States
• Language: English

Related Subjects

550900 -- Pathology
560000* -- Biomedical Sciences
Applied Studies
560300 -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOASSAY
CARCINOGENESIS
CORRELATIONS
EXTRAPOLATION
MAMMALS
MAN
MATHEMATICAL MODELS
MICE
NUMERICAL SOLUTION
PATHOGENESIS
PRIMATES
RATS
RELIABILITY
RODENTS
STATISTICAL MODELS
VERTEBRATES