Interspecies comparison of carcinogenic potency

Journal Article · Sun Dec 31 23:00:00 EST 1978 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287397909529817· OSTI ID:6219476

Crouch, E; Wilson, R

For guidance in decisions on how to safeguard humans from carcinogens, it is necessary to use data on carcinogenesis in animals. Attempts are made to discuss how such data, combined with human experience, may be used quantitatively in such decisions. It is demonstrated empirically that good correlations exist between different species for suitably defined carcinogenic potencies for various chemicals. This allows sufficient accuracy in extrapolating from animal data to human risk to support a logical scheme for the evaluation of such risks. Some recommendations for future research are given.

• Research Organization: Harvard Univ., Cambridge, MA
• OSTI ID: 6219476
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 5; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
560306 -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL MODELS
CARCINOGEN SCREENING
CARCINOGENESIS
CARCINOGENS
COMPARATIVE EVALUATIONS
CORRELATIONS
EXTRAPOLATION
HAZARDS
HEALTH HAZARDS
HUMAN POPULATIONS
NUMERICAL SOLUTION
PATHOGENESIS
POPULATIONS
RECOMMENDATIONS
SAFEGUARDS
SCREENING