Correlation between carcinogenic potency of chemicals in animals and humans
Twenty-three chemicals were selected for comparison of the carcinogenic potencies estimated from epidemiological data to those estimated from animal carcinogenesis bioassays. The chemicals were all those for which reasonably strong evidence of carcinogenicity could be found in humans or animals and for which suitable data could be obtained for quantifying carcinogenic potencies in both humans and animals. Many alternative methods of analyzing the bioassay data were investigated. Almost all of the methods yielded potency estimates that were highly correlated with potencies estimated from epidemiological data; correlations were highly statistically significant (p < 0.001), with the corresponding correlation coefficients ranging as high as 0.9. These findings provide support for the general use of animal data to evaluate carcinogenic potential in humans and also for the use of animal data to quantify human risk.
- Research Organization:
- Clement Associates, Inc., Ruston, LA (USA)
- OSTI ID:
- 6288869
- Journal Information:
- Risk Anal.; (United States), Journal Name: Risk Anal.; (United States) Vol. 8:4; ISSN RIAND
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AFLATOXIN
ANIMALS
ANTIGENS
AROMATICS
ARSENIC
ASBESTOS
BENZENE
BIOASSAY
BIOLOGICAL EFFECTS
CADMIUM
CARCINOGENESIS
CARCINOGENS
CHLORINATED ALIPHATIC HYDROCARBONS
CHLORINATED AROMATIC HYDROCARBONS
CHLOROFORM
CHROMIUM
CLASSIFICATION
CORRELATIONS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
EPIDEMIOLOGY
EPOXIDES
HALOGENATED ALIPHATIC HYDROCARBONS
HALOGENATED AROMATIC HYDROCARBONS
HYDROCARBONS
MAMMALS
MAN
MATERIALS
METALS
NEOPLASMS
NICKEL
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PATHOGENESIS
PRIMATES
SEMIMETALS
TOXIC MATERIALS
TOXINS
TRANSITION ELEMENTS
UPTAKE
VERTEBRATES