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Studies on the tumor initiating, tumor promoting, and tumor co-initiating properties of respiratory carcinogens

Conference ·
OSTI ID:5353326
; ;

With mouse skin as the bioassay model, the multifaceted behavior of chemicals and mixtures can be elucidated using the protocols of tumor initiation, tumor promotion, tumor co-initiation, and complete carcinogenesis. In addition to studies with individual respiratory carcinogens, we report the tumorigenic and carcinogenic effects of complex environmental mixtures. We sought to compare the potency of human respiratory carcinogens, based on epidemiological data, with the bioassay potency data obtained from mouse skin tumor initiation and mouse skin complete carcinogenesis experiments as well as the bioassay potency data obtained from short-term genetic toxicology bioassays. Three human respiratory carcinogens were used: emissions from coke ovens, emissions from roofing tar pots, and cigarette smoke. When the potency obtained from mouse skin tumor initiation experiments of these materials was compared with the potency based on human respiratory cancer, a surprisingly close correlation was observed. 10 refs., 18 figs., 5 tabs. (DT)

Research Organization:
Environmental Protection Agency, Research Triangle Park, NC (USA). Health Effects Research Lab.; Oak Ridge National Lab., TN (USA)
DOE Contract Number:
AC05-84OR21400
OSTI ID:
5353326
Report Number(s):
CONF-8406210-2; ON: DE85016387
Country of Publication:
United States
Language:
English

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Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ALKALINE EARTH METAL COMPOUNDS
ANIMALS
AROMATICS
ASPHALTS
BENZOPYRENE
BERYLLIUM COMPOUNDS
BERYLLIUM SULFATES
BITUMENS
BODY
CARCINOGEN SCREENING
CARCINOGENS
COAL TAR
COLLOIDS
CONDENSED AROMATICS
DATA
DISEASES
DISPERSIONS
ESTERS
EXHAUST GASES
EXPERIMENTAL DATA
FLUIDS
GASEOUS WASTES
GASES
HYDROCARBONS
INFORMATION
MAMMALS
MICE
NEOPLASMS
NICKEL COMPOUNDS
NICKEL SULFATES
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
OTHER ORGANIC COMPOUNDS
OXYGEN COMPOUNDS
PHORBOL ESTERS
PYRENE
RESIDUES
RODENTS
SCREENING
SKIN
SMOKES
SOLS
SULFATES
SULFUR COMPOUNDS
TAR
TOBACCO SMOKES
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
WASTES