Can carcinogenicity be predicted from chemical analysis and DNA adduction

Conference · Sat Oct 01 00:00:00 EDT 1988

OSTI ID:5941519

Mahlum, D. D.; Mann, D. LB.; Dankovic, D. A.; Springer, D. L.

Tumorigenicity of mixtures is often considered to be a sum of the tumorigenicity of individual components of the mixture. We have presented evidence that this may not be so for mixtures derived from the liquefaction of coal. Tumor initiation is considered to be a genetic event in which the DNA is altered by adduction by a carcinogenic chemical or by a physical agent such as ionizing radiation. DiGiovanni et al (1982) have presented evidence that mouse skin tumor initiating activity is closely correlated with the level of DNA adduction. In this paper, we examine the relationship between chemical composition of mixtures and their skin tumor initiating activity. We also examine the effect of mixtures on the skin tumor initiating activity and the adduction of DNA by benzo(a)pyrene (BaP). These studies involve predicting the carcinogenicity of mixtures from their chemical composition and the use of DNA adduct formation rather than chemical composition as it is a better indicator of tumor initiating activity. 4 refs., 6 figs., 1 tab.

• Research Organization: Pacific Northwest Lab., Richland, WA (USA)
• DOE Contract Number: AC06-76RL01830
• OSTI ID: 5941519
• Report Number(s): PNL-SA-16167; CONF-8810209-13; ON: DE89014931
• Country of Publication: United States
• Language: English

Related Subjects

550200 -- Biochemistry
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADDUCTS
BODY
CARCINOGENESIS
COAL LIQUIDS
DISEASES
DNA ADDUCTS
FLUIDS
FORECASTING
FRACTIONATION
LIQUIDS
MUTAGENS
NEOPLASMS
ORGANS
PATHOGENESIS
PRODUCTION
SEPARATION PROCESSES
SKIN