Toxicological interactions between carcinogenic and weakly carcinogenic mixtures in the mouse skin initiation-promotion system
Conference
·
OSTI ID:6331132
We previously observed that the carcinogenic activity of the neutral fraction of a coal gasifier tar was greater in the absence of the other tar components. Other investigators showed that the dermal tumor-initiating activity of benzo(a)pyrene (BaP) and the binding of BaP to mouse skin DNA was diminished when the BaP was administered in the presence of coal liquids. In the present study we found that the weakly tumorigenic polar neutral fraction of the gasifier tar diminished the tumor-initiating activity of the PAH-enriched fraction at one dose level, but not at another. 20 refs., 1 fig., 2 tabs.
- Research Organization:
- Argonne National Lab., IL (USA)
- DOE Contract Number:
- W-31109-ENG-38
- OSTI ID:
- 6331132
- Report Number(s):
- CONF-8510225-7; ON: DE86005571
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
AROMATICS
AZAARENES
AZOLES
CARBAZOLES
CARCINOGENESIS
CARCINOGENS
COAL TAR
ESTERS
FRACTIONATION
HETEROCYCLIC COMPOUNDS
INDOLES
MAMMALS
MICE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OTHER ORGANIC COMPOUNDS
PATHOGENESIS
PHORBOL ESTERS
POLYCYCLIC AROMATIC AMINES
PYRROLES
RODENTS
SEPARATION PROCESSES
TAR
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
AROMATICS
AZAARENES
AZOLES
CARBAZOLES
CARCINOGENESIS
CARCINOGENS
COAL TAR
ESTERS
FRACTIONATION
HETEROCYCLIC COMPOUNDS
INDOLES
MAMMALS
MICE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OTHER ORGANIC COMPOUNDS
PATHOGENESIS
PHORBOL ESTERS
POLYCYCLIC AROMATIC AMINES
PYRROLES
RODENTS
SEPARATION PROCESSES
TAR
VERTEBRATES