An overview of the report: Correlation between carcinogenic potency and the maximum tolerated dose: Implications for risk assessment
Journal Article
·
· Risk Analysis; (United States)
- Health and Welfare Canada, Ottawa, Ontario (Canada) Carleton Univ. Ottawa, Ontario (Canada)
- National Center for Toxicological Research, Jefferson, AR (United States)
- Univ. of Wisconsin, Madison, WI (United States)
- Health and Welfare Canada, Ottawa, Ontario (Canada)
Current practice in carcinogen bioassay calls for exposure of experimental animals at doses up to and including the maximum tolerated dose (MTD). Such studies have been used to compute measures of carcinogenic potency such as the TD[sub 50] as well as unit risk factors such as q[sub 1] for predicting low-dose risks. Recent studies have indicated that these measures of carcinogenic potency are highly correlated with the MTD. Carcinogenic potency has also been shown to be correlated with indicators of mutagenicity and toxicity. Correlation of the MTDs for rats and mice implies a corresponding correlation in TD[sub 50] values for these two species. The implications of these results for cancer risk assessment are examined in light of the large variation in potency among chemicals known to induce tumors in rodents. 119 refs., 2 figs., 4 tabs.
- OSTI ID:
- 5594211
- Journal Information:
- Risk Analysis; (United States), Journal Name: Risk Analysis; (United States) Vol. 13:4; ISSN 0272-4332; ISSN RIANDF
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560101* -- Biomedical Sciences
Applied Studies-- Radiation Effects-- Dosimetry & Monitoring-- (1992-)
560300 -- Chemicals Metabolism & Toxicology
61 RADIATION PROTECTION AND DOSIMETRY
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOASSAY
CARCINOGENESIS
CORRELATIONS
DISEASES
MAMMALS
MAXIMUM PERMISSIBLE DOSE
MUTAGENESIS
NEOPLASMS
PATHOGENESIS
RISK ASSESSMENT
RODENTS
SAFETY STANDARDS
STANDARDS
TOXICITY
VERTEBRATES
Applied Studies-- Radiation Effects-- Dosimetry & Monitoring-- (1992-)
560300 -- Chemicals Metabolism & Toxicology
61 RADIATION PROTECTION AND DOSIMETRY
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOASSAY
CARCINOGENESIS
CORRELATIONS
DISEASES
MAMMALS
MAXIMUM PERMISSIBLE DOSE
MUTAGENESIS
NEOPLASMS
PATHOGENESIS
RISK ASSESSMENT
RODENTS
SAFETY STANDARDS
STANDARDS
TOXICITY
VERTEBRATES