Identification of cis and trans components of a novel heat shock stress regulatory pathway in Saccharomyces cerevisiae

Journal Article · Fri Jan 01 04:00:00 EST 1993 · Molecular and Cellular Biology; (United States)

DOI:https://doi.org/10.1128/MCB.13.1.248· OSTI ID:6433027

Kobayashi, N; McEntee, K ^[1]

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1. Univ. of California Los Angeles School of Medicine (United States)

In Saccharomyces cerevisiae, the stress-responsive gene DDR2 is transcribed at elevated levels following heat shock or DNA damage. A pentanucleotide, CCCCT, has been identified as an essential component of the stress response sequence. This research demonstrates the ability of oligonucleotides containing CCCCT sequence to confer heat shock inducibility on the report gene and show that the presence of two such elements produces more than additive effects on induction. It also identify key cis- and transacting components of a novel heat shock stress response pathway in Saccharomyces cerevisiae.

• OSTI ID: 6433027
• Journal Information: Molecular and Cellular Biology; (United States), Journal Name: Molecular and Cellular Biology; (United States) Vol. 13:1; ISSN 0270-7306; ISSN MCEBD4
• Country of Publication: United States
• Language: English

Related Subjects

550400 -- Genetics
550700* -- Microbiology
59 BASIC BIOLOGICAL SCIENCES
BIOLOGICAL PATHWAYS
BIOLOGICAL STRESS
CELL CONSTITUENTS
CELL MEMBRANES
DISTRIBUTION
EUMYCOTA
FUNGI
GENE REGULATION
MEMBRANE PROTEINS
MEMBRANES
MICROORGANISMS
ORGANIC COMPOUNDS
PHYSIOLOGY
PLANTS
PROTEINS
SACCHAROMYCES
SACCHAROMYCES CEREVISIAE
SUBCELLULAR DISTRIBUTION
YEASTS