Effect of dietary selenium concentration and duration of selenium feeding on hepatic glutathione concentrations in rats
Journal Article
·
· Proc. Soc. Exp. Biol. Med.; (United States)
Studies were conducted in rats to determine the effect of dietary selenium (Se) concentration on hepatic glutathione concentrations and enzyme activities associated with the maintenance of the cellular glutathione status. Male rats were fed 0.1, 3.0, or 6.0 ppm Se as Na/sub 2/SeO/sub 3/ for 2, 4, or 6 weeks at which time they were killed and analyses were performed. Both 3.0 and 6.0 ppm Se caused a significant dose-dependent increase in hepatic-reduced glutathione (GSH) by 4 weeks of feeding compared to 0.1 ppm Se. The increase in GSH was preceded by significant, dose-dependent increases in oxidized glutathione (GSSG) as well as the GSSG to GSH ratio. Increases in GSSG and the GSSG to GSH ratio as well as in glutathione reductase and glucose-6-phosphate dehydrogenase activities were observed by 2 weeks of high Se feeding. The current findings substantiate previous results demonstrating effects of high Se on hepatic glutathione concentrations and further suggest that increased cellular GSSG concentrations or the GSSG to GSH ratio caused by 3.0 and 6.0 ppm dietary Se signals for adaptive changes in hepatic glutathione metabolism.
- Research Organization:
- Univ. of Wisconsin, Madison
- OSTI ID:
- 6425552
- Journal Information:
- Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Journal Issue: 2 Vol. 180:2; ISSN PSEBA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Hepatic glutathione metabolism and lipid peroxidation in response to excess dietary selenomethionine and selenite in mallard ducklings. [Anas platyrhynchos]
Association of mercury and selenium with altered glutathione metabolism and oxidative stress in diving ducks from the San Francisco Bay region, USA
Effects of different levels of selenium administered to rats in drinking water on distribution and glutathione peroxidase
Journal Article
·
Sat Dec 31 23:00:00 EST 1988
· Journal of Toxicology and Environmental Health; (USA)
·
OSTI ID:5078447
Association of mercury and selenium with altered glutathione metabolism and oxidative stress in diving ducks from the San Francisco Bay region, USA
Journal Article
·
Sat Jan 31 23:00:00 EST 1998
· Environmental Toxicology and Chemistry
·
OSTI ID:580745
Effects of different levels of selenium administered to rats in drinking water on distribution and glutathione peroxidase
Journal Article
·
Sat Jul 01 00:00:00 EDT 1978
· Res. Commun. Chem. Pathol. Pharmacol.; (United States)
·
OSTI ID:6468907
Related Subjects
550200 -- Biochemistry
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BODY
CHEMICAL REACTIONS
DATA
DIET
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELEMENTS
ENZYME ACTIVITY
ENZYMES
EXPERIMENTAL DATA
GLANDS
GLUTATHIONE
INFORMATION
INGESTION
INTAKE
KINETICS
LIVER
MAMMALS
METABOLISM
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
RATS
REACTION KINETICS
REDOX REACTIONS
RODENTS
SELENIUM
SEMIMETALS
VERTEBRATES
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BODY
CHEMICAL REACTIONS
DATA
DIET
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELEMENTS
ENZYME ACTIVITY
ENZYMES
EXPERIMENTAL DATA
GLANDS
GLUTATHIONE
INFORMATION
INGESTION
INTAKE
KINETICS
LIVER
MAMMALS
METABOLISM
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
RATS
REACTION KINETICS
REDOX REACTIONS
RODENTS
SELENIUM
SEMIMETALS
VERTEBRATES