Temperature-sensitive mutant TS 082 of vesicular stomatitis virus. I. Rescue at nonpermissive temperature by uv-irradiated virus
Temperature-sensitive mutant ts 082 of vesicular stomatitis virus efficiently complements with all the five known groups of ts mutants. This mutant is analyzed by its rescue at nonpermissive temperature with uv-irradiated virus. The existence of two targets of uv light is demonstrated that suggests rescue is mediated through two different complementation processes, gene/sup +/ survival and structural protein supply by the uv-irradiated virus. This last point is supported by rescue assays carried out in the absence of simultaneous protein synthesis. These features are also shared by the ts mutants of group II, suggesting that ts 082 might belong to complementation group II. The temperature-sensitive defect of ts 082 could be located in a domain different from the one which is mutated in the ts mutants previously classified in group II.
- Research Organization:
- Univ. de Paris-Sud, Orsay, France
- OSTI ID:
- 6424924
- Journal Information:
- Virology; (United States), Journal Name: Virology; (United States) Vol. 93:1; ISSN VIRLA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGY
DATA
DATA FORMS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
GENES
GENETICS
GRAPHS
INFORMATION
ISOLATED VALUES
MICROORGANISMS
MUTANTS
NUMERICAL DATA
ORGANIC COMPOUNDS
PARASITES
PROTEINS
RADIATION EFFECTS
RADIATIONS
SURVIVAL TIME
TEMPERATURE DEPENDENCE
ULTRAVIOLET RADIATION
VIRUSES