Synthesis and characterization of organohydrazino complexes of technetium, rhenium, and molybdenum with the [M({eta}{sup 1}-H{sub x}NNR)({eta}{sup 2}-H{sub y}NNR)] core and their relationship to radiolabeled organohydrazine-derivatives chemotactic peptides with diagnostic applications
- Syracuse Univ., NY (United States). Dept. of Chemistry
- Massachusetts Inst. of Tech., Cambridge, MA (United States). Chemistry Dept.; and others
In this paper, the authors present the details of the preparation of the imaging agent and its imaging properties. In order to define some structural possibilities for the coordination chemistry relevant to these reagents, they also present the results of investigations of the syntheses and structures of Tc, Mo, and Re complexes with hydrazinopyridine, which not only establish the formation of the robust unit, but also implicate chelate formation through the pyridine nitrogen as a significant structural determinant. The structures of the parent (bis)hydrazino-trichlorometalate core compounds are presented, allowing analysis of structural changes that occur when (2) protonation sites on the ligand change, (2) a different metal is employed, and (3) a different chelating hydrazine is utilized. The structures of the thiolate substitution products of these parent compounds are also presented. These derivatives demonstrate that rhenium and technetium have analogous substitution chemistry.
- Sponsoring Organization:
- USDOE, Washington, DC (United States)
- OSTI ID:
- 642394
- Journal Information:
- Inorganic Chemistry, Vol. 37, Issue 11; Other Information: PBD: 1 Jun 1998
- Country of Publication:
- United States
- Language:
- English
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