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Technetium(V) and rhenium(V) complexes of 2,3-bis(mercaptoacetamido)propanoate. Chelate ring stereochemsitry and influence on chemical and biological properties

Journal Article · · Journal of the American Chemical Society; (USA)
DOI:https://doi.org/10.1021/ja00171a019· OSTI ID:6793607
 [1]; ; ;  [2]
  1. NeoRx Corp., Seattle, WA (USA)
  2. Univ. of Washington, Seattle (USA)
+ Show Author Affiliations

Monoxo complexes of technetium(V) and rhenium(V) with 2,3-bis(mercaptoacetamido)propanoate (map) have been synthesized. The complexes with general formula (Ph{sub 4}X)(MO(map)) (where X = As, P; M = Tc, Re) were characterized by IR, visible-UV spectra, and negative ion fast atom bombardment spectroscopy. The chelate ring epimers were separated by HPLC (semipreparative reverse-phase C{sub 18}) isolated and crystallized as salts of (Ph{sub 4}X)(MO(map)). The structures of the two epimers (syn and anti) of technetium and one of the epimers (syn) of the rhenium complexes were determined by single-crystal X-ray analyses. All three complexes crystallize in the space group P2{sub 1}/c and have four formula units in the unit cell. In all of the three complexes, the metal (Tc, Re) is coordinated to one oxygen (yl) atom, two sulfur (thiolate) atoms, and two nitrogen atoms (amide) in a distorted square-pyramidal geometry. The position trans to the oxygen (yl) atom is vacant.

DOE Contract Number:
AC02-83ER60140
OSTI ID:
6793607
Journal Information:
Journal of the American Chemical Society; (USA), Journal Name: Journal of the American Chemical Society; (USA) Vol. 112:15; ISSN 0002-7863; ISSN JACSA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
COMPLEXES
CRYSTAL STRUCTURE
DATA
DATA ANALYSIS
DRUGS
EXPERIMENTAL DATA
INFORMATION
LABELLED COMPOUNDS
MEASURING INSTRUMENTS
MEASURING METHODS
NUMERICAL DATA
RADIOPHARMACEUTICALS
RHENIUM COMPLEXES
STEREOCHEMISTRY
SYNTHESIS
TECHNETIUM COMPLEXES
TRANSITION ELEMENT COMPLEXES