Technetium(V) and rhenium(V) complexes of 2,3-bis(mercaptoacetamido)propanoate. Chelate ring stereochemsitry and influence on chemical and biological properties

Journal Article · Wed Jul 18 00:00:00 EDT 1990 · Journal of the American Chemical Society; (USA)

DOI:https://doi.org/10.1021/ja00171a019· OSTI ID:6793607

Rao, T N ^[1]; Adhikesavalu, D; Camerman, A; Fritzberg, A R ^[2]

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1. NeoRx Corp., Seattle, WA (USA)
2. Univ. of Washington, Seattle (USA)

Monoxo complexes of technetium(V) and rhenium(V) with 2,3-bis(mercaptoacetamido)propanoate (map) have been synthesized. The complexes with general formula (Ph{sub 4}X)(MO(map)) (where X = As, P; M = Tc, Re) were characterized by IR, visible-UV spectra, and negative ion fast atom bombardment spectroscopy. The chelate ring epimers were separated by HPLC (semipreparative reverse-phase C{sub 18}) isolated and crystallized as salts of (Ph{sub 4}X)(MO(map)). The structures of the two epimers (syn and anti) of technetium and one of the epimers (syn) of the rhenium complexes were determined by single-crystal X-ray analyses. All three complexes crystallize in the space group P2{sub 1}/c and have four formula units in the unit cell. In all of the three complexes, the metal (Tc, Re) is coordinated to one oxygen (yl) atom, two sulfur (thiolate) atoms, and two nitrogen atoms (amide) in a distorted square-pyramidal geometry. The position trans to the oxygen (yl) atom is vacant.

• DOE Contract Number: AC02-83ER60140
• OSTI ID: 6793607
• Journal Information: Journal of the American Chemical Society; (USA), Vol. 112:15; ISSN 0002-7863
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
RADIOPHARMACEUTICALS
RHENIUM COMPLEXES
CRYSTAL STRUCTURE
SYNTHESIS
TECHNETIUM COMPLEXES
DATA ANALYSIS
EXPERIMENTAL DATA
MEASURING INSTRUMENTS
MEASURING METHODS
STEREOCHEMISTRY
COMPLEXES
DATA
DRUGS
INFORMATION
LABELLED COMPOUNDS
NUMERICAL DATA
TRANSITION ELEMENT COMPLEXES
550601* - Medicine- Unsealed Radionuclides in Diagnostics