The coordination chemistry of technetium and rhenium and applications to nuclear medicines. [Annual] technical report, April 1, 1993--December 31, 1993
The dramatic dependence of Re-binding to functionalized hydrazines on the nature of the coligands associated with the metal site has led to an examination of alkoxy and thiolato ligand types. The observation that multidentate thiolate ligands are highly effective in this latter role suggests the design and synthesis of new chelating polythiolate ligands with high binding affinities for radiometallic nuclides and of functionalized polythiolate ligands for the preparation of radionuclide-conjugated antibodies or peptides and the preparation and characterization of their complexes not only with the Group 7 metals Tc and Re but with the Group 13 metals Ga and In, which also possess radionuclides with useful properties. Since the rational design of these novel bifunctional conjugates requires a fundamental understanding of the coordination chemistry of relevant metals with polythiolate ligands whose syntheses and properties remain unexplored, effort has been directed toward the preparation of novel polythiolate ligands and the characterization of their complexes with Group 7 and Group 13 metals. This report describes studies on several complementary aspects of the coordination chemistry of the pyridinethiolate derived ligands 2-HSC{sub 5}NH{sub 3}-SiR{sub 3}, 2-HSC{sub 5}NH{sub 3}-6-SiR{sub 3} and 2-HSC{sub 5}NH{sub 2}-3,6-SiR{sub 3} and the potentially bifunctional polythiolate ligand HOOCCH{sub 2}Si(CH{sub 2}CH{sub 2}SH){sub 3} have been synthesized; of several aspects of rhenium-hydrazido and rhenium-thiolate chemistry have been developed; of Ga and In complexes of the 2-pyridinethiolate class of ligands have been synthesized and structurally characterized; and of the general coordination properties of the 2-pyrithinethiolate and related ligand types.
- Research Organization:
- Syracuse Univ., NY (United States)
- Sponsoring Organization:
- USDOE, Washington, DC (United States)
- DOE Contract Number:
- FG02-93ER61571
- OSTI ID:
- 10144275
- Report Number(s):
- CONF-9308226-1; ON: DE94010423; BR: KP0601000
- Resource Relation:
- Conference: Rhenium-Catecholato complexes and their reactivity with organohydrazines,Chicago, IL (United States),22-27 Aug 1993; Other Information: PBD: [1993]
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
TECHNETIUM COMPLEXES
LIGANDS
RHENIUM COMPLEXES
CHEMICAL PREPARATION
RADIOPHARMACEUTICALS
COORDINATION VALENCES
PYRIDINES
THIOLS
HYDRAZINE
LIQUID COLUMN CHROMATOGRAPHY
PROGRESS REPORT
550604
550601
400703
UNSEALED RADIONUCLIDES IN THERAPY
UNSEALED RADIONUCLIDES IN DIAGNOSTICS
RADIOISOTOPE PRODUCTION