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Ileal hyperplastic response to starvation in the rat

Journal Article · · Am. J. Physiol.; (United States)
OSTI ID:6411528
; ;

The ability to respond to changes in the external and internal environments is a fundamental characteristic of intestinal structure and function. The authors compared the responses of the rat proximal and distal small intestine to the stresses of fasting and refeeding in the rat. In the duodenum, 3 days of starvation caused villus and crypt hypoplasia, reduced incorporation of (TH)thymidine into crypt cells, decreased cell migration rate on the villus, and lowered specific and total activities of several cellular enzymes. These changes were reversed by 1 day of refeeding. In contrast, mucosal hypoplasia did not occur in the ileum during fasting, and the specific activities of the disaccharidases were increased after 3 days of starvation. However, ileal (TH)thymidine incorporation, thymidine kinase activity, and ornithine decarboxylase activity decreased during starvation. These effects were also reversed by refeeding. The results of these studies illustrate differing responses for the proximal and distal small intestine and suggest the presence of distinctly differing mechanisms for the control of their mucosal mass and enzyme activities.

Research Organization:
Columbia Univ., New York, NY
OSTI ID:
6411528
Journal Information:
Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States) Vol. 251:1; ISSN AJPHA
Country of Publication:
United States
Language:
English

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Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
AZINES
BIOLOGICAL EFFECTS
BODY
CARBON-CARBON LYASES
CARBOXY-LYASES
CELL PROLIFERATION
DECARBOXYLASES
DIGESTIVE SYSTEM
ENZYME ACTIVITY
ENZYMES
GASTROINTESTINAL TRACT
HETEROCYCLIC COMPOUNDS
INTESTINES
LABELLED COMPOUNDS
LYASES
MAMMALS
MEMBRANES
MUCOUS MEMBRANES
NUCLEOSIDES
NUCLEOTIDES
NUTRITIONAL DEFICIENCY
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PHOSPHORUS-GROUP TRANSFERASES
PHOSPHOTRANSFERASES
PHYSIOLOGY
PYRIMIDINES
RATS
RIBOSIDES
RODENTS
SMALL INTESTINE
THYMIDINE
TRANSFERASES
TRITIUM COMPOUNDS
VERTEBRATES