Evidence for rearrangement, amplification, and expression of c-myc in a human glioblastoma

Journal Article · Wed Jan 01 04:00:00 EST 1986 · Proc. Natl. Acad. Sci. U.S.A.; (United States)

DOI:https://doi.org/10.1073/pnas.83.2.470· OSTI ID:6410868

Trent, J; Meltzer, P; Rosenblum, M; Harsh, G; Kinzler, K; Mashal, R; Feinberg, A; Vogelstein, B

Amplified cellular genes are frequently manifested in one of two cytologically recognizable forms, double minutes or homogeneously staining regions. Additionally, evidence is accumulating that aberrant expression of cellular genes (including oncogenes) may be mediated by gene amplification. The authors now describe the amplification and expression of the cellular oncogene c-myc in double-minute-containing cells from a patient with glioblastoma multiforme, and they have shown that the amplification is associated with rearrangement of the c-myc gene. This finding further supports the common association of the myc gene family in neurogenic tumors and provides evidence of myc gene amplification in human brain cancer.

• Research Organization: Univ. of Arizona, Tucson
• OSTI ID: 6410868
• Journal Information: Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 83:2; ISSN PNASA
• Country of Publication: United States
• Language: English

Related Subjects

550401* -- Genetics-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGY
CHROMOSOMES
CYTOLOGY
DAYS LIVING RADIOISOTOPES
DISEASES
GENES
GENETICS
GLIOMAS
ISOTOPES
KARYOTYPE
LIGHT NUCLEI
MOLECULAR BIOLOGY
NEOPLASMS
NUCLEI
NUCLEOTIDES
ODD-ODD NUCLEI
ONCOGENES
ORGANIC COMPOUNDS
PATIENTS
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
RADIOISOTOPES
TUMOR CELLS