Long-term follow-up study of compensated low-dose /sup 131/I therapy for Graves' disease
We treated 187 patients who had Graves' disease with low-dose radioactive iodide (/sup 131/I), using a protocol that included a compensation for thyroid size. The incidence of early hypothyroidism (12 per cent) was acceptably low in the first year after /sup 131/I treatment, but we found a cumulative high incidence (up to 76 per cent) at the end of the 11th year. In contrast, the incidence of permanent hypothyroidism was relatively stable in 166 surgically treated patients, increasing from 19 to 27 per cent at the end of 11 years. Among 122 medically treated patients, only 40 per cent entered remission, and hypothyroidism developed in 2 per cent during the same period of follow-up. The long-term incidence of hypothyroidism in our patients treated with low-dose /sup 131/I therapy was much higher than that found in earlier studies using a comparable dose. Our study suggests that it will be difficult to modify therapy with /sup 131/I alone to produce both early control of thyrotoxicosis and a low incidence of hypothyroidism.
- Research Organization:
- Department of Medicine, University of Chicago, IL
- OSTI ID:
- 6405221
- Journal Information:
- N.Engl. J. Med.; (United States), Vol. 311:7
- Country of Publication:
- United States
- Language:
- English
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Long-term follow-up results in children and adolescents treated with radioactive iodine ($sup 131$I) for hyperthyroidism
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