Long-term follow-up results in children and adolescents treated with radioactive iodine ($sup 131$I) for hyperthyroidism

Journal Article · Thu Jan 23 00:00:00 EST 1975 · New Engl. J. Med., v. 292, no. 4, pp. 167-170

OSTI ID:4129568

Safa, A M; Schumacher, O P; Rodriguez-Antunez, A

To evaluate the long-term results of $sup 131$I therapy for children, the course of 87 patients (three to 18 years old, 24 boys and 63 girls) treated from 1949 through 1968, for hyperthyroidism due to Graves's disease was studied. Dose of $sup 131$I per patient ranged from 2.9 to 31 mCi (mean +- S. D., 9.75 +- 6.5). Patients were followed for five to 24 years (mean, 12.3 +- 3.5). Hyperthyroidism was controlled in 85 within one to 14 months (mean, 3.3 +- 2.6). Recurrence of thyrotoxicosis due to toxic diffuse goiter, observed in only one case after 11 years, was successfully re-treated with $sup 131$I. Reproductive history and health status of the progeny of $sup 131$I-treated patients were not different from those of the general population. No deaths and no cancer or leukemia were observed in patients or their offspring. The major cause of goiter regrowth was Hashimoto's thyroiditis. Hypothyroidism developed in 35 of 76 patients (46 percent). $sup 131$I deserves further use in treatment of hyperthyroid children with Graves's disease. (auth)

• Research Organization: Cleveland Clinic Foundation
• NSA Number: NSA-33-009606
• OSTI ID: 4129568
• Journal Information: New Engl. J. Med., v. 292, no. 4, pp. 167-170, Other Information: Orig. Receipt Date: 30-JUN-76
• Country of Publication: United States
• Language: English

Related Subjects

N48610* -Life Sciences-Radionuclide Effects (Internal Source)-Man
560161* -Biomedical Sciences
Applied Studies-Radiation Effects-Radionuclide Effects-Internal Source-Man
*GOITER- RADIOTHERAPY
*HYPERTHYROIDISM- RADIOTHERAPY
*RADIOTHERAPY- SIDE EFFECTS
*THYROIDITIS- RADIOTHERAPY
CHILDREN
IODINE 131
PATIENTS
THYROID