Health risk assessment of trans-1,2-dichloroethylene in California drinking water

Technical Report · Tue Jan 24 04:00:00 EST 1989

OSTI ID:6399800

Hall, L C; Mallon, B; Hsieh, P; McKone, T E

This document presents an assessment of the potential health risks associated with exposure to trans-1,2-dichloroethylene (trans-1,2-DCE) dissolved in California drinking waters. This assessment is being provided to the California Department of Health Services (CDHS) for the development of drinking-water standards to manage the health risks of trans-1,2-DCE exposure. Other assessments required in the risk-assessment process include analyses of the technical and economic feasibilities of treating water supplies contaminated with trans-1,2-DCE. A primary goal of this health-risk assessment is to evaluate dose-response relationships for observed and potential toxic end points of trans-1,2-DCE in order to define dose rates that can be used to establish standards that will protect members of the general public from adverse health effects resulting solely from water-based exposures to trans-1,2-DCE. We also analyze the extent of human exposures attributable to trans-1,2-DCE-contaminated groundwater in California. The document consists of seven sections, plus an appendix. Our assessment begins in Section 2 with a review of the uses of trans-1,2-DCE, its environmental chemistry, and concentrations measured in different environmental media. The next section provides an overview of published studies on the absorption and metabolism of trans-1,2-DCE. In Section 4, we review studies of the acute and subchronic toxicity of trans-1,2-DCE to animals and humans.

• Research Organization: Lawrence Livermore National Lab., CA (USA)
• DOE Contract Number: W-7405-ENG-48
• OSTI ID: 6399800
• Report Number(s): UCRL-21062; ON: DE89007229
• Country of Publication: United States
• Language: English

Related Subjects

500200* -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
BODY
BODY AREAS
CALIFORNIA
CARCINOGENESIS
CARDIOVASCULAR SYSTEM
CONTAMINATION
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
DRINKING WATER
ENVIRONMENTAL EXPOSURE
ENVIRONMENTAL TRANSPORT
EYES
FACE
FEDERAL REGION IX
GENE MUTATIONS
GLANDS
GROUND WATER
HAZARDS
HEAD
HEALTH HAZARDS
HEART
HUMAN POPULATIONS
HYDROGEN COMPOUNDS
KIDNEYS
LIVER
LUNGS
MASS TRANSFER
MUTATIONS
NORTH AMERICA
ORGANIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PATHOGENESIS
POPULATIONS
RESPIRATORY SYSTEM
RISK ASSESSMENT
SENSE ORGANS
SKIN
TOXICITY
USA
WATER