Acute and subchronic toxicity in rats of trans-1,2-dichloro-ethylene in drinking water

Journal Article · Mon Feb 01 04:00:00 EST 1988 · Journal of the American College of Toxicology; (USA)

OSTI ID:6832969

Hayes, J R; Condie, L W; Egle, J L; Borzelleca, J F ^[1]

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1. Medical College of Virginia, Richmond (USA)

Trans-1,2-dichloroethylene was administered by gavage (acute studies) or in drinking water (subchronic studies) to male and female Sprague-Dawley derived Charles River rats. The acute oral LD50 was 7,902 mg/kg for males and 9,939 mg/kg for females. Decreased activity, ataxia, and depressed respiration preceded death. In the subchronic study, rats received theoretical daily doses of 500, 2,500, and 3,000 mg/kg body weight/day for 90 consecutive days. The actual daily doses were 402, 1,314, and 3,114 mg/kg for males and 353, 12,257, and 2,809 mg/kg for females. There were no compound-related deaths. There were no consistently significant compound-related dose-dependent adverse effects on any of the hematological, serological, or urinary parameters evaluated. There were dose-dependent increases in kidney weights and ratios in females. There were no compound-related gross or historical effects. No specific organ site toxicity could be identified. The toxicity from exposure to trans-1,2-dichloroethylene in drinking water apparently is low and probably does not constitute a serious health hazard. 14 refs., 4 tabs.

• OSTI ID: 6832969
• Journal Information: Journal of the American College of Toxicology; (USA), Journal Name: Journal of the American College of Toxicology; (USA) Vol. 6:4; ISSN JACTD; ISSN 0730-0913
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ANIMALS
CHLORINATED ALIPHATIC HYDROCARBONS
CHRONIC EXPOSURE
CONTAMINATION
DOSE-RESPONSE RELATIONSHIPS
DRINKING WATER
HALOGENATED ALIPHATIC HYDROCARBONS
HYDROGEN COMPOUNDS
MAMMALS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
OXYGEN COMPOUNDS
RATS
RODENTS
SEX DEPENDENCE
TOXICITY
VERTEBRATES
WATER