Acute and subchronic toxicity in rats of trans-1,2-dichloro-ethylene in drinking water
- Medical College of Virginia, Richmond (USA)
Trans-1,2-dichloroethylene was administered by gavage (acute studies) or in drinking water (subchronic studies) to male and female Sprague-Dawley derived Charles River rats. The acute oral LD50 was 7,902 mg/kg for males and 9,939 mg/kg for females. Decreased activity, ataxia, and depressed respiration preceded death. In the subchronic study, rats received theoretical daily doses of 500, 2,500, and 3,000 mg/kg body weight/day for 90 consecutive days. The actual daily doses were 402, 1,314, and 3,114 mg/kg for males and 353, 12,257, and 2,809 mg/kg for females. There were no compound-related deaths. There were no consistently significant compound-related dose-dependent adverse effects on any of the hematological, serological, or urinary parameters evaluated. There were dose-dependent increases in kidney weights and ratios in females. There were no compound-related gross or historical effects. No specific organ site toxicity could be identified. The toxicity from exposure to trans-1,2-dichloroethylene in drinking water apparently is low and probably does not constitute a serious health hazard. 14 refs., 4 tabs.
- OSTI ID:
- 6832969
- Journal Information:
- Journal of the American College of Toxicology; (USA), Vol. 6:4; ISSN 0730-0913
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CHLORINATED ALIPHATIC HYDROCARBONS
TOXICITY
DRINKING WATER
CONTAMINATION
ACUTE EXPOSURE
CHRONIC EXPOSURE
DOSE-RESPONSE RELATIONSHIPS
RATS
SEX DEPENDENCE
ANIMALS
HALOGENATED ALIPHATIC HYDROCARBONS
HYDROGEN COMPOUNDS
MAMMALS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
OXYGEN COMPOUNDS
RODENTS
VERTEBRATES
WATER
560300* - Chemicals Metabolism & Toxicology