Experimentally induced intestinal metaplasia in Wistar rats by x-ray irradiation
Journal Article
·
· Gastroenterology; (United States)
OSTI ID:6394113
The gastric region of 5-week-old female Wistar rats was irradiated daily with 500 rad of x-ray up to a total of six times. Goblet cells and marker enzymes of the small intestine, such as lactase, trehalase, and maltase, appeared in the pyloric region of the glandular stomach of the rats from the 1st week after final irradiation. Intestinal type crypt without Paneth cells was observed from the 8th week. Sucrase activity appeared from the 26th week. Intestinal metaplasia with Paneth cells appeared from the 71st week. The number of goblet cells, intestinal type crypts, and Paneth cells increased with age. Gastric adenocarcinoma did not develop after irradiation.
- Research Organization:
- Hiroshima Univ., Japan
- OSTI ID:
- 6394113
- Journal Information:
- Gastroenterology; (United States), Journal Name: Gastroenterology; (United States) Vol. 75:5; ISSN GASTA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DIGESTIVE SYSTEM
DISEASES
ELECTROMAGNETIC RADIATION
ENZYME ACTIVITY
FRACTIONATED IRRADIATION
GASTROINTESTINAL TRACT
INTESTINES
IONIZING RADIATIONS
IRRADIATION
MAMMALS
NEOPLASMS
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RATS
RODENTS
VERTEBRATES
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DIGESTIVE SYSTEM
DISEASES
ELECTROMAGNETIC RADIATION
ENZYME ACTIVITY
FRACTIONATED IRRADIATION
GASTROINTESTINAL TRACT
INTESTINES
IONIZING RADIATIONS
IRRADIATION
MAMMALS
NEOPLASMS
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RATS
RODENTS
VERTEBRATES
X RADIATION