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Relationship between gastric tumorigenesis and intestinal metaplasia in rats given x-radiation and/or N-methyl-N'-nitro-N-nitrosoguanidine

Journal Article · · J. Natl. Cancer Inst.; (United States)
OSTI ID:5423555
;
The influence of x-radiation and N-methyl-N'-nitro-N-nitrosoguanidine ((MNNG) CAS: 70-25-7) on intestinal metaplasia and gastric tumorigenesis was examined in 5-week-old male Crj:CD(SD) rats. The animals were treated either with two 10-Gy fractions of x-rays separated by 3 days for a total of 20 Gy to the gastric region and/or with MNNG orally for 4 months. Simultaneous treatment with x-rays and MNNG (group II) and MNNG only (group IV) induced gastric tumors in the majority of the animals. Sequential treatment with x-radiation and MNNG, either x-ray 2 months prior to MNNG (group I) or MNNG 2 months prior to x-ray (group III), resulted in a lower incidence of gastric tumors as compared with the incidence after treatment with MNNG alone. The frequencies of intestinal metaplasia in the x-irradiated groups (groups I and V) were significantly higher than those in group II, III, or IV. The incidence of intestinal metaplasia and of gastric tumor was inversely proportional. These results indicate that intestinal metaplasia does not play a role in the induction of gastric tumors by MNNG.
Research Organization:
Hiroshima Univ., Japan
OSTI ID:
5423555
Journal Information:
J. Natl. Cancer Inst.; (United States), Journal Name: J. Natl. Cancer Inst.; (United States) Vol. 5; ISSN JNCIA
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARCINOGENESIS
DIGESTIVE SYSTEM
ELECTROMAGNETIC RADIATION
EXPERIMENTAL NEOPLASMS
GASTROINTESTINAL TRACT
IONIZING RADIATIONS
MAMMALS
MATHEMATICS
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOGENESIS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RATS
REGRESSION ANALYSIS
RODENTS
STATISTICS
SYNERGISM
VERTEBRATES
X RADIATION