Adaptive response and enhancement of N-methyl-N-nitro-N-nitrosoguanidine mutagenesis by chloramphenicol in Streptomyces fradiae
Journal Article
·
· J. Bacteriol.; (United States)
OSTI ID:5457135
Streptomyces fradiae expressed an adaptive response to treatment with small doses of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) that caused a reduction in mutagenesis by treatment with larger doses of MNNG. Treatment of S. fradiae with high levels of MNNG in the presence of chloramphenicol caused enhancement of mutagenesis, independent of the adaptive response.
- Research Organization:
- Lilly Research Labs., Indianapolis, IN
- OSTI ID:
- 5457135
- Journal Information:
- J. Bacteriol.; (United States), Journal Name: J. Bacteriol.; (United States) Vol. 164:2; ISSN JOBAA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550400 -- Genetics
550700 -- Microbiology
560302* -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
BACTERIA
BIOLOGICAL ADAPTATION
BIOLOGICAL EFFECTS
CARBONIC ACID DERIVATIVES
CHLORAMPHENICOL
DRUGS
GENETIC EFFECTS
GUANIDINES
MICROORGANISMS
MUTAGENESIS
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
STREPTOMYCES
550700 -- Microbiology
560302* -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
BACTERIA
BIOLOGICAL ADAPTATION
BIOLOGICAL EFFECTS
CARBONIC ACID DERIVATIVES
CHLORAMPHENICOL
DRUGS
GENETIC EFFECTS
GUANIDINES
MICROORGANISMS
MUTAGENESIS
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
STREPTOMYCES