Radiation-associated lung cancer: A comparison of the histology of lung cancers in uranium miners and survivors of the atomic bombings of Hiroshima and Nagasaki

Journal Article · Sat May 01 00:00:00 EDT 1993 · Radiation Research; (United States)

DOI:https://doi.org/10.2307/3578464· OSTI ID:6385426

Land, C E; Shimosato, Y; Saccomanno, G; Tokuoka, S; Auerbach, O; Tateishi, R; Greenberg, S D; Nambu, S; Carter, D; Akiba, S ^[1]

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1. National Cancer Institute, Bethesda, MD (United States)

A binational panel of Japanese and American pulmonary pathologists reviewed tissue slides of lung cancer cases diagnosed among Japanese A-bomb survivors and American uranium miners and classified the cases according to histological subtype. Blind reviews were completed on slides from 92 uranium miners and 108 A-bomb survivors, without knowledge of population, sex, age, smoking history, or level of radiation exposure. Consensus diagnoses were obtained with respect to principal subtype, including squamous-cell cancer, small-cell cancer, adenocarcinoma, and less frequent subtypes. The results were analyzed in terms of population, radiation dose, and smoking history. As expected, the proportion of squamous-cell cancer was positively related to smoking history in both populations. The relative frequencies of small-cell cancer and adenocarcinoma were very different in the two populations, but this difference was accounted for adequately by differences in radiation dose or, more specifically, dose-based relative risk estimates based on published data. Radiation-induced cancers appeared more likely to be of the small-cell subtype, and less likely to be adenocarcinomas, in both populations. The data appeared to require no additional explanation in terms of radiation quality (alpha particles vs gamma rays), uniform or local irradiation, inhaled vs external radiation source, or other population difference.

• OSTI ID: 6385426
• Journal Information: Radiation Research; (United States), Vol. 134:2; ISSN 0033-7587
• Country of Publication: United States
• Language: English

Related Subjects

61 RADIATION PROTECTION AND DOSIMETRY
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS
A-BOMB SURVIVORS
ENVIRONMENTAL EXPOSURE
NEOPLASMS
RADIATION DOSES
MINERS
OCCUPATIONAL EXPOSURE
BIOLOGICAL RADIATION EFFECTS
COMPARATIVE EVALUATIONS
ELDERLY PEOPLE
HIROSHIMA
HISTOLOGY
JAPAN
NAGASAKI
RADIOLOGICAL WARFARE
TOBACCO SMOKES
URANIUM MINES
ADULTS
AEROSOLS
AGE GROUPS
AGED ADULTS
ANIMALS
ASIA
BIOLOGICAL EFFECTS
COLLOIDS
DEVELOPED COUNTRIES
DISEASES
DISPERSIONS
DOSES
EVALUATION
HUMAN POPULATIONS
MAMMALS
MAN
MINES
MINORITY GROUPS
PERSONNEL
POPULATIONS
PRIMATES
RADIATION EFFECTS
RESIDUES
SMOKES
SOLS
UNDERGROUND FACILITIES
VERTEBRATES
WARFARE
560101* - Biomedical Sciences
Applied Studies- Radiation Effects- Dosimetry & Monitoring- (1992-)
560151 - Radiation Effects on Animals- Man
550900 - Pathology
054000 - Nuclear Fuels- Health & Safety