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Historical Changes in Histological Diagnosis of Lung Cancer

Journal Article · · Journal of Epidemiology
 [1];  [2];  [3]
  1. Radiation Effects Research Foundation, Hiroshima (Japan); DOE/OSTI
  2. JA Onomichi General Hospital, Hiroshima (Japan)
  3. Radiation Effects Research Foundation, Hiroshima (Japan)
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Background: Histological classification of lung cancer is essential for investigations of carcinogenesis and treatment selection. We examined the temporal changes of lung cancer histological subtypes. Methods: Lung cancer cases diagnosed in the Life Span Study cohort between 1958 and 1999 were collected from tumor registries (TR), mainly consisting of population-based cancer registries. A total of 1,025 cases were histologically reviewed according to the World Health Organization 2004 Classification by a panel of pathologists (PP). Sensitivity and specificity of diagnoses in TR were calculated, assuming that the diagnosis by PP was the gold standard. Results: Sensitivity and specificity were 0.91 and 0.92 for adenocarcinoma (AD), respectively, and 0.92 and 0.94, respectively, for squamous cell carcinoma (SQ). They were similar for AD and SQ throughout the observation period. For small cell carcinoma (SM), sensitivity was low until about 1980 (0.47 in 1958–1969, and 0.61 in 1970–1979) and then became higher thereafter (0.98 in 1980–1989, and 0.95 in 1990–1999), whereas specificity was high during the whole period (range 0.99 to 1.00). Among 45 cases that were not reported as SM in TR but diagnosed as SM by PP, 16 cases were recorded as undifferentiated carcinoma in TR. Conclusion: Diagnosis of AD and SQ of lung cancer were generally consistent between TR records and PP review, but SMs tended to be coded as other histological types until the 1970s.
Research Organization:
Radiation Effects Research Foundation, Hiroshima (Japan)
Sponsoring Organization:
USDOE Office of Science (SC)
Grant/Contract Number:
FG02-00ER41132
OSTI ID:
1628011
Journal Information:
Journal of Epidemiology, Journal Name: Journal of Epidemiology Journal Issue: 6 Vol. 29; ISSN 0917-5040
Publisher:
Japan Epidemiological Association (JEA)Copyright Statement
Country of Publication:
United States
Language:
English

References (10)

An updated report on the trends in cancer incidence and mortality in Japan, 1958–2013 journal January 2015
Introduction to The 2015 World Health Organization Classification of Tumors of the Lung, Pleura, Thymus, and Heart journal September 2015
Reproducibility of Diagnosis and Its Influence on the Distribution of Lung Cancer by Histologic Type in Osaka, Japan journal January 2000
Radiation and Smoking Effects on Lung Cancer Incidence among Atomic Bomb Survivors journal April 2010
Radiation and Smoking Effects on Lung Cancer Incidence by Histological Types Among Atomic Bomb Survivors journal September 2012
Lung Cancer Histologic Type in the Surveillance, Epidemiology, and End Results Registry Versus Independent Review journal July 2004
The 2015 World Health Organization Classification of Lung Tumors journal September 2015
A Systematic Review of the Interobserver Variability for Histology in the Differentiation between Squamous and Nonsquamous Non-small Cell Lung Cancer journal January 2011
Radiation and Smoking Effects on Lung Cancer Incidence among Atomic Bomb Survivors journal April 2010
Radiation and Smoking Effects on Lung Cancer Incidence by Histological Types Among Atomic Bomb Survivors journal September 2012

Cited By (1)

Automated Ventricular Tachyarrhythmia Recognition. journal April 1997

Figures / Tables (2)

Table 1(p. 2)table Table 1
Table 2(p. 2)table Table 2

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Related Subjects

60 APPLIED LIFE SCIENCES
Public
Environmental & Occupational Health
histological diagnosis
lung cancer
reproducibility