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Response of Chinese hamster ovary cells to fast neutron radiotherapy beams. III. Variation in relative biological effectiveness with position in the cell cycle

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3574779· OSTI ID:6381998
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The response of synchronized Chinese hamster cells to fast neutrons was investigated. Two different neutron beams (mean energies 7 and 21 MeV) produced at the Texas A and M University Variable Energy Cyclotron were used in these studies. The results showed that the variation in sensitivity of cells to neutrons as a function of position in the cell cycle was substantially reduced compared to the variation observed with /sup 60/Co ..gamma.. rays. The degree of this reduction was similar for the two neutron beams studied. A detailed analysis of single-dose survival curves generated at radiation-sensitive and radiation-resistant positions in the cell cycle demonstrated that the relative biological effectiveness (RBE) of the sensitive moiety was much smaller than that of the resistant cells. For example, the RBE at the clinically relevant neutron dose of 75 rad was 4.7 for the mid- to late-S phase cells, 2.2 for the mitotic cells, and 1.7 for the G/sub 1//S cells. Moreover, the RBE/sub n/..gamma.. of the sensitive moiety was dose independent while that of the resistant cells strongly depended on dose.
Research Organization:
Univ. of Texas Health Sciences Center, Houston
OSTI ID:
6381998
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 76:2; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BARYONS
BODY
CELL CULTURES
CELL CYCLE
COMPARATIVE EVALUATIONS
DOSE-RESPONSE RELATIONSHIPS
ELEMENTARY PARTICLES
ENERGY RANGE
FAST NEUTRONS
FEMALE GENITALS
FERMIONS
GONADS
HADRONS
HAMSTERS
IN VITRO
IRRADIATION
MAMMALS
MEV RANGE
MEV RANGE 01-10
MEV RANGE 10-100
NEUTRONS
NUCLEONS
ORGANS
OVARIES
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RBE
RODENTS
SURVIVAL CURVES
SYNCHRONOUS CULTURES
VERTEBRATES