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Response of Chinese hamster ovary cells to fast neutron radiotherapy beams. [Gamma radiation]

Thesis/Dissertation ·
OSTI ID:7218569
In October of 1972 M. D. Anderson Hospital and Tumor Institute of The University of Texas System Cancer Center began human cancer fast neutron radiotherapy trials, utilizing the 16 and 50 MeV peak energy fast neutron beams generated with the Texas A and M variable energy cyclotron. Prior to the commencement of these trials, mammalian cellular radiobiological studies were begun on the beams to be used in the trials, the 16 MeV beam (produced with 16 MeV deuterons bombarding a beryllium target) and the 50 MeV beam (produced with 50 MeV deuterons bombarding a beryllium target). Chinese hamster ovary (CHO) cells in tissue culture, irradiated in a tissue-equivalent phantom under various specific conditions, were used to determine the following for each fast neutron and a /sup 60/Co gamma ray radiotherapy beam: The relative biological effectiveness (RBE) as a function of dose. The oxygen enhancement ratio (OER) and gain factor (G). The variation of each of these parameters with depth in tissue-equivalent fluid. The cellular recovery capabilities from sublethal and potentially lethal radiation damage. The variation of radiation sensitivity as a function of position in the cell cycle. The RBE, as compared to /sup 60/Co gamma rays, decreases with increasing dose for both fast neutron beams from about 3.4 to near 2.0, with a 15% decrease in RBE for the fast neutron energy change from 16 to 50 MeV. There is no variation in RBE with depth in tissue-equivalent fluid, through 10-15 cm.
Research Organization:
Texas Univ., Houston (USA). Graduate School of Biomedical Sciences
OSTI ID:
7218569
Country of Publication:
United States
Language:
English

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Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BARYONS
BEAMS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
FAST NEUTRONS
FERMIONS
GAMMA RADIATION
HADRONS
HAMSTERS
IONIZING RADIATIONS
MAMMALS
MEDICINE
NEUTRON BEAMS
NEUTRONS
NUCLEAR MEDICINE
NUCLEON BEAMS
NUCLEONS
OXYGEN ENHANCEMENT RATIO
PARTICLE BEAMS
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
RADIOSENSITIVITY
RADIOTHERAPY
RBE
RODENTS
THERAPY
VERTEBRATES