Respiratory response of guinea pigs to sulfuric acid mist

Journal Article · Wed Jan 01 00:00:00 EST 1958 · AMA Arch. Ind. Health; (United States)

OSTI ID:6380747

Amdur, M O

Guinea pigs were exposed to 23 to 42 mg/m/sup 3/ acid mist with a mass median diameter of 0.8, 2.5, or 7 ..mu..m for 1-h periods. Significant increase in resistance at all levels and sizes was observed. There was a concurrent decrease in compliance for 2.5- and 7-..mu..m sizes with exception of lowest level of exposure. Dose-effect with resistance vs concentration shows smaller sizes were more deleterious. The 2.5 ..mu..m were more harmful at higher concentrations (above approx. 15 mg/m/sup 3/). The 0.8-..mu..m particles produced a rapid response suggesting bronchoconstriction as the mechanism (change in resistance proportionately greater than change in compliance). This was similar to irritant gases. Conversely, 2.5- and 7-..mu..m particles acted slower and change in resistance paralleled the drop in compliance. High concentrations evoked edema and atelectasis. This was interpreted as closure of main bronchi rather than general constriction. Response was consistent with expected penetration.

• OSTI ID: 6380747
• Journal Information: AMA Arch. Ind. Health; (United States), Vol. 18
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
SULFURIC ACID
BIOLOGICAL EFFECTS
AEROSOLS
DEPOSITION
EDEMA
GUINEA PIGS
LUNGS
PARTICLE SIZE
PARTICLES
PATHOLOGICAL CHANGES
RESPIRATORY SYSTEM
RETENTION
ANIMALS
BODY
COLLOIDS
DISEASES
DISPERSIONS
HYDROGEN COMPOUNDS
INORGANIC ACIDS
MAMMALS
ORGANS
RODENTS
SIZE
SOLS
SYMPTOMS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)