Respiratory response of guinea pigs to sulfuric acid mist

Journal Article · Wed Jan 01 04:00:00 EST 1958 · AMA Arch. Ind. Health; (United States)

OSTI ID:6380747

Amdur, M O

Guinea pigs were exposed to 23 to 42 mg/m/sup 3/ acid mist with a mass median diameter of 0.8, 2.5, or 7 ..mu..m for 1-h periods. Significant increase in resistance at all levels and sizes was observed. There was a concurrent decrease in compliance for 2.5- and 7-..mu..m sizes with exception of lowest level of exposure. Dose-effect with resistance vs concentration shows smaller sizes were more deleterious. The 2.5 ..mu..m were more harmful at higher concentrations (above approx. 15 mg/m/sup 3/). The 0.8-..mu..m particles produced a rapid response suggesting bronchoconstriction as the mechanism (change in resistance proportionately greater than change in compliance). This was similar to irritant gases. Conversely, 2.5- and 7-..mu..m particles acted slower and change in resistance paralleled the drop in compliance. High concentrations evoked edema and atelectasis. This was interpreted as closure of main bronchi rather than general constriction. Response was consistent with expected penetration.

• OSTI ID: 6380747
• Journal Information: AMA Arch. Ind. Health; (United States), Journal Name: AMA Arch. Ind. Health; (United States) Vol. 18; ISSN AMIHA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
BIOLOGICAL EFFECTS
BODY
COLLOIDS
DEPOSITION
DISEASES
DISPERSIONS
EDEMA
GUINEA PIGS
HYDROGEN COMPOUNDS
INORGANIC ACIDS
LUNGS
MAMMALS
ORGANS
PARTICLE SIZE
PARTICLES
PATHOLOGICAL CHANGES
RESPIRATORY SYSTEM
RETENTION
RODENTS
SIZE
SOLS
SULFURIC ACID
SYMPTOMS
VERTEBRATES