Adenocarcinoma of the gallbladder in guinea pigs. [Sex-dependent incidence following whole-body. gamma. - or x irradiation]

Journal Article · Thu Feb 01 04:00:00 EST 1979 · J. Natl. Cancer Inst.; (United States)

OSTI ID:6380710

Hoch-Ligeti, C ^[1]; Congdon, C C; Deringer, M K; Stewart, H L

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1. National Cancer Inst., Bethesda, MD

Adenocarcinoma of the gallbladder developed in 17 of 68 untreated and in 26 of 83 irradiated guinea pigs of inbred strains 2 and 13. The carcinomas spread widely by direct extension and through lymphatic and blood vessels to lymph nodes, mesenteries, omenta, abdominal wall, liver, lungs, bones, and spleen. Whole-body exposure to gamma or x radiation increased both the number of tumors and metastases in male inbred guinea pigs but not in females. Significantly fewer (9 of 98) noninbred than inbred guinea pigs developed gallbladder carcinomas after irradiation. In 9 untreated noninbred guinea pigs gallbladder carcinomas were not found. Inasmuch as the effect of irradiation was not dose-dependent, an indirect systemic effect of irradiation was postulated. This is the first report on the occurrence of spontaneous gallbladder adenocarcinomas in guinea pigs.

• OSTI ID: 6380710
• Journal Information: J. Natl. Cancer Inst.; (United States), Journal Name: J. Natl. Cancer Inst.; (United States) Vol. 62:2; ISSN JNCIA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BILIARY TRACT
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL VARIABILITY
CARCINOMAS
CHRONIC EXPOSURE
CHRONIC IRRADIATION
DIGESTIVE SYSTEM
DISEASES
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
GAMMA RADIATION
GENETIC VARIABILITY
GUINEA PIGS
IONIZING RADIATIONS
IRRADIATION
MAMMALS
NEOPLASMS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY
RODENTS
SEX DEPENDENCE
VERTEBRATES
WHOLE-BODY IRRADIATION
X RADIATION