Killing of glucose-deprived hypoxic cells with moderate hyperthermia. [HeLa cells]

Journal Article · Tue Aug 01 04:00:00 EDT 1978 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3574919· OSTI ID:6379898

Kim, J H; Kim, S H; Hahn, E W

Investigations were carried out to determine the importance of glucose as a modifying factor for hyperthermic cellular damage. HeLa S-3 cells were heated under oxic and hypoxic conditions, in the presence and absence of D-glucose. Temperatures as low as 41/sup 0/C selectively enhanced killing of the glucose deprived hypoxic cell. Glucose deprivation (37/sup 0/C, 2 hr) or heat alone (41/sup 0/C for 2 hr in regular medium with glucose) produced minimal cell kill under oxic or hypoxic conditions. No enhancement was seen with hyperthermia under oxic condition in the absence of glucose. The result suggests that the interplay between glucose concentration is important for hyperthermic cell kill.

• Research Organization: Memorial Sloan-Kettering Cancer Center, New York, NY
• OSTI ID: 6379898
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 75:2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
BIOLOGICAL EFFECTS
BODY TEMPERATURE
CARBOHYDRATES
CELL KILLING
CRYOGENIC FLUIDS
ELEMENTS
FLUIDS
GLUCOSE
HELA CELLS
HEXOSES
HYPERTHERMIA
MONOSACCHARIDES
NONMETALS
ORGANIC COMPOUNDS
OXYGEN
SACCHARIDES